000			01627 am a2200169 4500
001			2257
020			_c0.00
040			_aLung Cancer, Volume 12, Suppl 3, Pages S77 - S83
082			_aPUBLICATIONS ARCHIVE CARN
100			_aCarney, Desmond. _932888
245			_aCarboplatin/etoposide combination chemotherapy in the treatment of poor prognosis patients with small cell lung cancer.
260			_c1995
490			_aStaff Publications _vStaff Publications- Carney, Desmond
500			_aA print copy of this article is held in the Oncology Resource Centre.
650			_aAdvances in the treatment of SCLC have been slow but sure over the past decade. It is now recognized that a small subset of patients may be cured of this disease, particularly with combined modality treatment with radiation therapy and systemic chemotherapy. However, perhaps only 25 of all patients will be candidates for this intensive/combined modality approach. Therefore, there is a need to identify effective combination chemotherapy regimens that can be easily administered to the remaining 75 of poor prognosis SCLC patients. Our studies and those of others would suggest that the combination of carboplatin and oral etoposide is a highly effective regimen for the treatment of these patients with results equal to and comparable with more intensive schedules. The ease of administration of this combination with acceptable toxicity would suggest that for such a subset of patients it may be the treatment of choice against which other combination schedules should be compared. _935086
710			_aST. LUKE'S PUBLICATION ARCHIVE _932511
999			_a2257 _c7450 _d7450