Wall and Melzack's textbook of pain / edited by Stephen B. McMahon [and others].

McMahon's name appears first on the 5th edition.

Includes bibliographical references and index.

Print version record.

Apply the latest scientific and clinical advances with Wall & Melzack's Textbook of Pain, 6th Edition. Drs. Stephen McMahon, Martin Koltzenburg, Irene Tracey, and Dennis C. Turk, along with more than 125 other leading authorities, present all of the latest knowledge about the genetics, neurophysiology, psychology, and assessment of every type of pain syndrome. They also provide practical guidance on the full range of today's pharmacologic, interventional, electrostimulative, physiotherapeutic, and psychological management options. Benefit from the international, multidisciplinary knowledge and experience of a "who's who" of international authorities in pain medicine, neurology, neurosurgery, neuroscience, psychiatry, psychology, physical medicine and rehabilitation, palliative medicine, and other relevant fields. Access the complete contents online anytime, anywhere at www.expertconsult.com.

Section 1. Neurobiology of pain -- section 2. Assessment and psychology of pain -- section 3. Pharmacology and treatment of pain -- section 4. Clinical states/deep somatic tissue -- section 5. Clinical states/viscera -- section 6. Clinical states/headache and facial pain -- section 7. Clinical states/neuropathic pain -- section 8. Clinical states/cancer pain.

Neurobiology of pain. Peripheral mechanisms of cutaneous nociception -- Molecular biology of sensory transduction -- Inflammatory mediators and modulators of pain -- Microglia: critical mediators of pain hypersensitivity after peripheral nerve injury -- Neuroanatomical substrates of spinal nociception -- Spinal cord plasticity and pain -- Representation of pain in the brain -- Central nervous system mechanisms of pain modulation -- Development of pain pathways and mechanisms -- Genetics of pain -- Animal models of pain -- Ascending projection systems -- Autonomic, endocrine, and immune interactions in acute and chronic pain -- Itch -- Assessment and psychology of pain. Gender differences in pain and its relief -- Epidemiology of pain -- Emotion, motivation, and pain -- Cognitive and learning aspects -- Psychiatric pain-associated co-morbidities -- Studies of pain in human subjects -- Pain measurement in adult patients -- Pain in older persons -- Measurement and assessment of pediatric pain -- Assessment of pain beliefs, coping, and function -- Hypnotic analgesia -- Pain, opiates, and addiction -- Placebo analgesia -- Pharmacology and treatment of pain. Spinal pharmacology of nociceptive transmission -- Methods of therapeutic trials -- Opioids: basic mechanisms -- Opioids: clinical use -- Cyclooxygenase inhibitors: basic aspects -- Cyclooxygenase inhibitors: clinical use -- Antidepressant analgesics -- Mechanism of action of anticonvulsants as analgesic drugs -- Anticonvulsants: clinical -- Local aesthetic blocks and epidurals -- Cannabinoids -- Analgesic drugs in development -- Neurosurgical approaches to the treatment of pain -- Spinal cord and brain stimulation -- The cognitive-behavioral approach to pain management -- A critical appraisal of complementary and alternative medicine -- Clinical states/deep somatic tissue. Joint pain: basic mechanisms -- Basic mechanisms of muscle pain -- Postoperative pain and its management -- Osteoarthritis and rheumatoid arthritis -- Fibromyalgia syndrome and myofascial pain syndrome -- Low back pain -- Non-specific arm pain -- Clinical states/viscera. Visceral pain: basic mehanisms -- Thoracic pain -- A clinical perspective on abdominal pain -- Genitourinary pain -- Obstetric pain -- Clinical states/headache and facial pain. Trigeminal mechanisms of nociception -- Acute and chronic orofacial and dental pain -- Migraine and the trigeminal autonomic cephalagias -- Tension-type headache -- Pain in and around the eye -- Clinical states/neuropathic pain. Neuropathic pain: pathophysiological response of nerves to injury -- Animal models of experimental neuropathic pain -- Central consequences of peripheral nerve damage -- Phantom limb -- Painful peripheral neuropathies -- Trigeminal and glossopharyngeal neuralgia -- Complex regional pain syndromes -- Pain following spinal cord injury -- Central pain -- Pharmacological therapy of neuropathic pain -- Surgery for back and neck pain (including radiculopathies) -- Clinical sates/cancer pain. Cancer pain: causes, consequences, and therapeutic opportunities -- Cancer pain assessment and syndromes -- Analgesic therapy and palliative care in children -- Cancer pain: treatment overview -- Pain control in the care of the dying.

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