Alzheimer's disease : life course perspectives on risk reduction / Amy R. Borenstein, Ph.D., M.P.H. and James A. Mortimer, Ph.D., University of South Florida, Department of Epidemiology and Biostatistics, Department of Neurology, Tampa, FL, USA.

Online resource; title from resource home page (ClinicalKey, viewed June 20, 2017).

Includes bibliographical references and index.

The "first" case -- Clinical appearance, progression, and classification -- Epidemiologic definition of a case -- Neuropathology of Alzheimer's disease -- The threshold model of dementia -- The prevalence of Alzheimer's disease -- The incidence of Alzheimer's disease -- Survival and mortality in Alzheimer's disease -- Introduction to the analytic epidemiology of Alzheimer's disease -- Family history, genetics, and down syndrome -- Early-life factors -- Traumatic brain injury -- Cigarette smoking and alcohol consumption -- Vascular disease -- Diet -- Physical activity -- Cognitive activity -- Social engagement -- Nonsteroidal anti-inflammatory drugs, hormone replacement therapy, and anticholinergic medications -- Prodromal markers of disease or causal risk factors? Depression, olfaction, and subjective memory complaints -- Fluid, imaging, and cognitive biomarkers -- Risk assessment and prevention of Alzheimer's disease -- Summary and recommendations.

Alzheimer's Disease: Lifecourse Perspectives on Risk Reduction summarizes the growing body of knowledge on the distribution and causes of Alzheimer's disease (AD) in human populations, providing the reader with knowledge on how we define the disease and what its risk and protective factors are in the context of a life-course approach. At the conclusion of the book, the reader will understand why Alzheimer's disease likely begins at conception, then progresses through early-life and adult risk factors that ultimately impact the balance between pathologic insults in the brain and the ability of the brain to modify disease symptoms. In contrast to edited volumes that may have little cohesion, this book focuses on an integrated life-course approach to the epidemiology of dementia, in particular, Alzheimer's disease.

Elsevier Elsevier ClinicalKey eBooks - WAYFless access