hli logo
Image from Coce

New therapeutics for traumatic brain injury : prevention of secondary brain damage and enhancement of repair and regeneration / edited by Kim A. Heidenreich.

Contributor(s): Material type: TextTextPublisher: London : Academic Press is an imprint of Elsevier, [2017]Copyright date: ©2017Description: 1 online resource (xxv, 325 pages) : illustrations (some color)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9780128027011
  • 0128027010
Subject(s): Genre/Form: Additional physical formats: Print version:: New therapeutics for traumatic brain injury.DDC classification:
  • 617.4810443 23
LOC classification:
  • RC387.5
NLM classification:
  • 2017 B-071
  • WL 354
Online resources:
Contents:
Part I: Interventional therapies for TBI previously or currently in phase 3 clinical trials. Why did the phase III clinical trials for progesterone in TBI fail? An analysis of three potentially critical factors / D.G. Stein, R.B. Howard, I. Sayeed -- Hypothermia for traumatic brain injury: current evidence and future directions / H. Mtaweh, D. Simon, M.J. Bell -- The future of TBI: hyperbaric oxygen as a primary therapeutic approach / B. Miskin, L.A. Fox -- Part II: Repurposing FDA approved drugs for TBI treatment. Erythropoietin and its derivatives: mechanisms of neuroprotection and challenges in clinical translation / T. Bogoslovsky, J.D. Bernstock, K. Kenney, C. Moore, R. Diaz-Arrastia -- Atorvastatin in the treatment of traumatic brain injury / A.N. Sen, S.P. Gopinath, C.S. Robertson -- The application of glibenclamide in traumatic brain injury / D.S. Hersh, J.M. Simard, H.M. Eisenberg -- Perispinal etanercept for traumatic brain injury / E. Tobinick, H. Rodriguez-Romanacce, R. Kinssies, N. Kim -- Part III: Interventional drugs for TBI in phase 1-2 clinical trials. Nitric oxide synthase inhibitors in traumatic brain injury / R. Schinzel, F. Tegtmeier -- Management of paroxysmal sympathetic hyperactivity after traumatic brain injury / L.D. Wilson, T.C. Leath, M.B. Patel -- Part IV: Interventional drugs for TBI in preclinical development. The use of estrogen for the treatment of traumatic brain injury / W.J. Hubbard, I.H. Chaudry -- Voltage-gated calcium channel blockers for the treatment of traumatic brain injury / G.G. Gurkoff, K. Shahlaie, B.G. Lyeth, R.F. Berman -- 5-lipoxygenase-activating protein inhibitors: promising drugs for treating acute and chronic neuroinflammation following brain injury / K.A. Heidenreich, C.E. Corser-Jensen -- Carbonyl scavenging as an antioxidant neuroprotective strategy for acute traumatic brain injury / J.E. Cebak, I.N. Singh, J.A. Wang, R.L. Hill, J.R. Kulbe, E.D. Hall -- TrkB receptor agonist 7,8-Dihydroxyflavone and its therapeutic potential for traumatic brain injury / J. Romeika, M. Wurzelmann, D. Sun -- Ceftriaxone treatment of TBI / M.Q. Hameed, A. Rotenberg -- Part V: Drugs for TBI rehabilitation. Memantine: a safe and tolerable NMDA antagonist with potential benefits in traumatic brain injury / M.A. Keiski -- Interventional drugs for TBI Rehabilitation of cognitive impairment: the cholinesterase inhibitor rivastigmine / M.A. Hernandez-Tejada, O. Brawman-Mintzer -- Docosahexaenoic acid and omega 3 fatty acids / M.E. Schober -- Treatment of mood disorders following traumatic brain injury / H.L. Lin, R.E. Jorge
Summary: "New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury"--Publisher's description.
Item type: eBook List(s) this item appears in: National ClinicalKey eBooks
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Collection Shelving location Call number Status Date due Barcode Item holds
eBook eBook eLibrary eLibrary Health Library Ireland eBook Collection online ebook Available EB1248
Total holds: 0

Includes bibliographical references and index.

Part I: Interventional therapies for TBI previously or currently in phase 3 clinical trials. Why did the phase III clinical trials for progesterone in TBI fail? An analysis of three potentially critical factors / D.G. Stein, R.B. Howard, I. Sayeed -- Hypothermia for traumatic brain injury: current evidence and future directions / H. Mtaweh, D. Simon, M.J. Bell -- The future of TBI: hyperbaric oxygen as a primary therapeutic approach / B. Miskin, L.A. Fox -- Part II: Repurposing FDA approved drugs for TBI treatment. Erythropoietin and its derivatives: mechanisms of neuroprotection and challenges in clinical translation / T. Bogoslovsky, J.D. Bernstock, K. Kenney, C. Moore, R. Diaz-Arrastia -- Atorvastatin in the treatment of traumatic brain injury / A.N. Sen, S.P. Gopinath, C.S. Robertson -- The application of glibenclamide in traumatic brain injury / D.S. Hersh, J.M. Simard, H.M. Eisenberg -- Perispinal etanercept for traumatic brain injury / E. Tobinick, H. Rodriguez-Romanacce, R. Kinssies, N. Kim -- Part III: Interventional drugs for TBI in phase 1-2 clinical trials. Nitric oxide synthase inhibitors in traumatic brain injury / R. Schinzel, F. Tegtmeier -- Management of paroxysmal sympathetic hyperactivity after traumatic brain injury / L.D. Wilson, T.C. Leath, M.B. Patel -- Part IV: Interventional drugs for TBI in preclinical development. The use of estrogen for the treatment of traumatic brain injury / W.J. Hubbard, I.H. Chaudry -- Voltage-gated calcium channel blockers for the treatment of traumatic brain injury / G.G. Gurkoff, K. Shahlaie, B.G. Lyeth, R.F. Berman -- 5-lipoxygenase-activating protein inhibitors: promising drugs for treating acute and chronic neuroinflammation following brain injury / K.A. Heidenreich, C.E. Corser-Jensen -- Carbonyl scavenging as an antioxidant neuroprotective strategy for acute traumatic brain injury / J.E. Cebak, I.N. Singh, J.A. Wang, R.L. Hill, J.R. Kulbe, E.D. Hall -- TrkB receptor agonist 7,8-Dihydroxyflavone and its therapeutic potential for traumatic brain injury / J. Romeika, M. Wurzelmann, D. Sun -- Ceftriaxone treatment of TBI / M.Q. Hameed, A. Rotenberg -- Part V: Drugs for TBI rehabilitation. Memantine: a safe and tolerable NMDA antagonist with potential benefits in traumatic brain injury / M.A. Keiski -- Interventional drugs for TBI Rehabilitation of cognitive impairment: the cholinesterase inhibitor rivastigmine / M.A. Hernandez-Tejada, O. Brawman-Mintzer -- Docosahexaenoic acid and omega 3 fatty acids / M.E. Schober -- Treatment of mood disorders following traumatic brain injury / H.L. Lin, R.E. Jorge

"New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury"--Publisher's description.

Online resource; title from electronic title page (ScienceDirect viewed March 27, 2018).

Elsevier Elsevier ClinicalKey eBooks - WAYFless access

There are no comments on this title.

to post a comment.