The molecular basis of cancer / [edited by] John Mendelsohn, Joe W. Gray, Peter M. Howley, Mark A. Israel, Craig B. Thompson.

Includes bibliographical references and index.

Cancer: A Genetic Disorder -- Oncogenes and Signal Transduction -- Tumor Suppressor Genes -- DNA Repair Pathways and Human Cancer -- Epigenetics and Cancer -- Infectious Agents and Cancer -- Environmental Carcinogenesis -- Animal Models: Flies, Fish, and Yeast -- Genetic Mouse Models of Cancer -- Cancer Stem Cells and the Microenvironment -- Regulation of the Cell Cycle -- Cell Growth -- The Metabolism of Cell Growth and Proliferation -- Apoptosis, Necrosis, and Autophagy -- Cellular Senescence -- The Role of the Microenvironment in Tumor Initiation, Progression, and Metastasis -- Tumor Angiogenesis -- Invasion and Metastasis -- Inflammation and Cancer -- Cancer Systems Biology: The Future -- Biomarkers for Assessing Risk of Cancer -- Protein Biomarkers for Detecting Cancer: Molecular Screening -- The Technology of Analyzing Nucleic Acids in Cancer -- Understanding and Using Information about Cancer Genomes -- High-Content Analysis with Cellular and Tissue Systems Biology: A Bridge between Cancer Cell Biology and Tissue-Based Diagnostics -- Molecular Genetics of Acute Lymphoblastic Leukemia -- Molecular Biology of Childhood Neoplasms -- Biology of Adult Myelocytic Leukemia and Myelodysplasia -- Lymphoma -- Multiple Myeloma -- Molecular Mechanisms of Esophageal Cancer -- Molecular Basis of Lung Cancer -- The Molecular Pathogenesis of Head and Neck Cancer -- Colon and Rectal Cancer -- Molecular Pathogenesis of Pancreatic Adenocarcinoma -- The Molecular Biology of Breast Cancer -- Molecular Pathogenesis of Ovarian Cancer -- Molecular Basis of Prostate Cancer -- Molecular Abnormalities in Kidney Cancer -- The Biology of Primary Brain Tumors -- Epithelial Skin Cancer -- Molecular Basis for Treating Cutaneous Melanoma -- Thyroid Cancer -- Soft Tissue Sarcomas -- From Bench to Bedside with Targeted Therapies -- Cancer Therapeutics -- Natural and Acquired Resistance to Cancer Therapies -- Phase I Trials Today -- Pharmacogenomics -- Monoclonal Antibodies for the Treatment of Cancer -- Cancer and the Cellular Immune Response -- Cancer Immunotherapy with Vaccines and Checkpoint Blockade -- Interferons -- Gene Therapy and Oncolytic Viruses -- RNA as a Therapeutic Molecule -- Heat Shock Protein 90 and the Proteasome: Housekeeping Proteins That Are Also Molecular Targets for Cancer Therapy -- Hematopoietic Growth Factors and Cytokines -- Cancer Chemoprevention -- Molecular Pathology.

Print version record.

The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Detailed descriptions of topics from molecular abnormalities in common cancers to new approaches for cancer therapy equip you to understand and apply the complexities of ongoing research in everyday clinical application. Effectively determine the course of malignancy and design appropriate treatment protocols by understanding the scientific underpinnings of cancer. Visually grasp and retain difficult concepts easily thanks to a user-friendly format with abundant full-color figures. Find critical information quickly with chapters following a logical sequence that moves from pathogenesis to therapy.

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