TY  - BOOK
AU  - Armstrong, John, G.
AU  - Zelefsky, M.J.
AU  - Leibel, Steven A.
ED  - ST. LUKE'S PUBLICATION ARCHIVE
TI  - Strategy for dose escalation using 3-dimensional conformal radiation therapy for lung cancer 
T2  - Staff Publications  
U1  - PUBLICATIONS ARCHIVE ARMS 
PY  - 1995///
KW  - PURPOSE: Local failure is a major obstacle to the cure of locally advanced non-small-cell lung cancer. 3-Dimensional conformal radiation therapy (3-DCRT) selects optimal treatment parameters to increase dose to tumor and reduce normal tissue dose, potentially permitting dose escalation. There are several ongoing trials of dose escalation using 3-dimensional conformal radiation therapy for non-small-cell lung cancer. We performed this analysis to determine if data derived from dose volume histograms could be used as the basis for designing the method of dose escalation in these trials. ""METHODS AND MATERIALS: Between 1990 and 1993, 31 patients were treated with 3-DCRT and had complete normal tissue dose volume histograms created as part of the planning process. The stage distribution was stage I/TI 13, stage IHa in 45, and stage Illb in 42. The median radiation dose to gross disease was 70.2 Gy (52.2�;72 Gy). Elective mediastinal irradiation (50.4 Gy) was administered to 52 (16/31) of patients. RESULTS: Thr toxicity encountered in this experience was pulmonary. Dose-volume-histogram data were used to analyze the predictors of toxicity and showed a correlation between risk of pulmonary toxicity and indices of dose to lung parenchyma. Grade 3 or higher pulmonary toxicityoccurred in 38 (3/8) of pts with																																																										
ER  -