Dose escalation of chart in non-small cell lung cancer: is three-dimensional conformal radiation therapy really necessary?
Material type:![Text](/opac-tmpl/lib/famfamfam/BK.png)
- PURPOSE: To evaluate, preclinically, the potential for dose escalation of continuous, hyperfractionated, accelerated radiation therapy (CHART) for non small-cell lung cancer (NSCLC), we examined the strategy of omission of elective nodal irradiation with and without the application of three-dimensional conformal radiation technology (3DCRT). METHODS AND MATERIALS: 2D, conventional therapy plans were designed according to the specifications of CHART for 18 patients with NSCLC (Stages Ib, IIb, IIIa, and IIIb). Further plans were generated with the omission of elective nodal irradiation (ENI) from the treatment portals (2D minus ENI plans [2D-ENI plans]). Both sets were inserted in the patient's planning computed tomographies (CTs). These reconstructed plans were then compared to alternative, three-dimensional treatment plans which had been generated de novo, with the omission of ENI: 3D minus elective nodal irradiation (3D-ENI plans). Dose delivery to the planning target volumes (PTVs) and to the organs at risk were compared between the 3 sets of corresponding plans. The potential for dose escalation of each patient's 2D-ENI and 3D-ENI plan beyond 54 Gy, standard to CHART, was also determined. RESULTS: PTV coverage was suboptimal in the 2D CHART and the 2D-ENI plans. Only in the 3D-ENI plans did 100 of the PTV get
- PUBLICATIONS ARCHIVE PHYS
Item type | Current library | Home library | Shelving location | Call number | Status | Date due | Barcode | Item holds | |
---|---|---|---|---|---|---|---|---|---|
2 Week Loan | St. Luke’s Radiation Oncology Network Dublin | St. Luke’s Radiation Oncology Network Dublin | AR | PUBLICATIONS ARCHIVE PHYS (Browse shelf(Opens below)) | Available | 39015000016306 |
Total holds: 0
Browsing St. Luke’s Radiation Oncology Network Dublin shelves, Shelving location: AR Close shelf browser (Hides shelf browser)
The print version of this article is held in the Oncology Resource Centre.
There are no comments on this title.
Log in to your account to post a comment.