Sjogren's syndrome : novel insights in pathogenic, clinical and therapeutic aspects / edited by Roberto Gerli ; co-edited by Elena Bartoloni, Alessia Alunno.

Includes bibliographical references.

Introduction : history of Sjögren's syndrome -- Clinical features -- Management of Sjögren's syndrome -- Classification criteria for Sjögren's syndrome -- Imaging procedures useful for the diagnosis of Sjögren's syndrome : abnormalities of the major salivary glands -- Sjögren's syndrome--associated lymphoma -- Spontaneous and inducible animal models of Sjögren's syndrome -- Genetics, genomics, gene expression profiling, and epigenetics in Sjögren's syndrome -- Autoantigens and autoantibodies in the pathogenesis of Sjögren's syndrome -- Sjögren's syndrome and environmental factors -- Histology of Sjögren's syndrome -- Glandular epithelium : innocent bystander or leading actor? -- T cells in the pathogenesis of Sjögren's syndrome : more than just Th1 and Th2 -- B lymphocytes in primary Sjögren's syndrome -- Cytokines, chemokines, and the innate immune system in Sjögren's syndrome -- Autoantibodies and autoantigens in Sjögren's syndrome -- Outcome measures in Sjögren's syndrome and perspectives in clinical trial design -- Novel therapeutic strategies in Sjögren's syndrome : b-cell targeting -- Novel therapeutic strategies in Sjögren's syndrome : t-cell targeting -- New biological avenues for Sjögren's syndrome.

Online resource; title from resource home page (ClinicalKey, viewed May 10, 2017).

"Sjogren's Syndrome: Novel Insights in Pathogenic, Clinical and Therapeutic Aspects provides the reader with an overview of current knowledge about Sjogren's Syndrome. The book summarizes the huge amount of literature concerning related advances in genetic background, pathogenesis, clinical picture, and therapeutic approaches. It integrates basic immunology concepts, clinical aspects, and pharmacological issues. Scientific progress has allowed us to unmask novel pathogenic mechanisms, to perform genome wide studies, and to identify clinical and serological features associated with different disease subsets and, eventually, different disease prognoses. In addition, the increasing knowledge about SS pathogenesis provides the rationale to employ targeted therapies in SS as has already occurred in rheumatoid arthritis and systemic lupus erythematosus"--Publisher's description.

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