Fundamental immunology / editor, William E. Paul.

Formerly CIP. Uk

Includes bibliographical references and index.

Section I: Introduction -- The immune system / William E. Paul.

Section II: Organization and evolution of the immune system -- Lymphoid tissues and organs / Eitan M. Akirav, Shan Liao, and Nancy H. Ruddle -- Evolution of the immune system / Martin F. Flajnik and Louis Du Pasquier.

Section III: Immunoglobulins and B lymphocytes -- Immunoglobulins: structure and function / Harry W. Schroeder, Jr., David Wald, and Neil S. Greenspan -- Antigen-antibody interactions and monoclonal antibodies / Jay A. Berzofsky, Ira J. Berkower, and Suzanne L. Epstein -- Immunoglobulins: molecular genetics / Edward Max -- B lymphocyte development and biology / Richard R. Hardy -- B lymphocyte signaling mechanisms and activation / Anthony L. DeFranco -- B lymphocyte biology / Michael McHeyzer-Williams.

Section IV: T lymphocytes -- T cell antigen receptors / Mark M. Davis and Yueh-Hsiu Chien -- T lymphocyte signaling mechanisms and activation / Gary A. Koretzky -- Development of T cells / Ellen V. Rothenberg and Mary A. Yui -- Peripheral T lymphocyte responses and function / Steven L. Reiner.

Section V: The intersection of innate and adaptive immunity -- The innate immune system / Ruslan Medzhitov -- Dendritic cells / Muriel Moser -- Natural killer cells / Wayne M. Yokoyama -- NKT cells and other innatelike T and B lineages / Albert Bendelac -- Macrophages and phagocytosis / Siamon Gordon -- Major histocompatibility complex (MHC) molecules: structure, function, and genetics / David H. Margulies ... [et al.] -- Cell biology of antigen processing and presentation / L�elia Delamarre and Ira Mellman.

Section VI: Regulation and effector functions of the immune response -- Immunogenicity and antigen structure / Jay A. Berzofsky and Ira J. Berkower -- Fc receptors and their role in immune regulation and inflammation / Jeffrey V. Ravetch and Falk Nimmerjahn -- Type I cytokines and interferons and their receptors / Warren J. Leonard -- Interleukin- 1 family of ligands and receptors / Charles A. Dinarello -- TNF-related cytokines in immunity / Carl F. Ware -- Chemokines / Philip M. Murphy -- Programmed cell death / Nicolas Bid�ere, Helen C. Su, and Michael J. Lenardo -- Immunologic memory / Stephen P. Schoenberger and Shane Crotty -- Immunologic tolerance / Ronald H. Schwartz -- Regulatory/suppressor T cells / Ethan M. Shevach -- The mucosal immune system / Hiroshi Kiyono ... [et al.] -- Neural immune interactions / Jeanette I. Webster Marketon and Esther M. Sternberg -- Complement / Cornelia Speth ... [et al.] -- Cytotoxic T lymphocytes / R. Chris Bleackley.

Section VII: Immunity to infectious agents -- The immune response to parasites / David L. Sacks ... [et al.] -- Immunity to viruses / Hildegund Ertl -- Immune responses to intracellular bacteria / Eric Pamer -- Immunity to extracellular bacteria / Jeffrey N. Weiser and Moon H. Nahm -- Immunology of HIV infection / Norman L. Letvin -- Vaccines / G.J.V. Nossal.

Section VIII: Immunologic mechanisms in disease -- Systemic autoimmunity / Betty Diamond -- Organ-specific autoimmunity / Matthias G. von Herrath and Dirk Homann -- Immunological mechanisms of allergic disease / Marsha Wills-Karp -- Transplantation immunology / Megan Sykes, Kathryn Wood, and David H. Sachs -- Tumor immunology / Nicholas P. Restifo, Paul F. Robbins, and Steven A. Rosenberg -- Primary immunodeficiency diseases / Rebecca H. Buckley.

This title provides an overview of the rapidly expanding field of immunology, with bioscience information critical to understanding how the immune system functions. Insightful discussions describe the role the immune system plays in the prevention and pathogenesis of disease.