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N$T |
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eng |
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rda |
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1105562446 |
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1141443645 |
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| International Standard Book Number |
9780128099667 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
0128099666 |
| Qualifying information |
(electronic bk.) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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9780128099650 |
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(hardcover) |
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0128099658 |
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(hardcover) |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
612.3/99 |
| Edition number |
23 |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Vitamin D. |
| Number of part/section of a work |
Volume 1, |
| Name of part/section of a work |
Biochemistry, physiology and diagnostics / |
| Statement of responsibility, etc. |
editor-in-chief, David Feldman, senior associate editor, J. Wesley Pike, associate editors, Roger Bouillon [and 3 others]. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
London ; |
| -- |
San Diego, CA : |
| Name of producer, publisher, distributor, manufacturer |
Academic Press is an imprint of Elsevier, |
| Date of production, publication, distribution, manufacture, or copyright notice |
[2018] |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
©2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
1 online resource (xxxvii, pages) : |
| Other physical details |
illustrations (chiefly color), color portraits |
| 500 ## - GENERAL NOTE |
|---|
| General note |
Revised edition of: Vitamin D / editor-in-chief, David Feldman; associate editors, J. Wesley Pike, John S. Adams. 3rd ed. 2011. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Vitamin D. |
| Authority record control number or standard number |
http://id.loc.gov/authorities/subjects/sh85143982 |
| 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Vitamin D |
| 650 #4 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Vitamin D. |
| 650 #6 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Vitamine D. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
MEDICAL |
| General subdivision |
Physiology. |
| Source of heading or term |
bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
SCIENCE |
| General subdivision |
Life Sciences |
| -- |
Human Anatomy & Physiology. |
| Source of heading or term |
bisacsh |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Vitamin D. |
| Source of heading or term |
fast |
| Authority record control number or standard number |
(OCoLC)fst01168206 |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Feldman, David, |
| Dates associated with a name |
1939- |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Pike, J. Wesley, |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bouillon, R., |
| Relator term |
editor. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="https://go.openathens.net/redirector/hse.ie?url=https%3a%2f%2fwww.clinicalkey.com%2fdura%2fbrowse%2fbookChapter%2f3-s2.0-C20150059214">https://go.openathens.net/redirector/hse.ie?url=https%3a%2f%2fwww.clinicalkey.com%2fdura%2fbrowse%2fbookChapter%2f3-s2.0-C20150059214</a> |
| Link text |
Access ebook online |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
eBook |
| Suppress in OPAC |
Display on Opac |
| 246 30 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
Biochemistry, physiology and diagnostics |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Linkage |
880-01 |
| Formatted contents note |
Section I: History, chemistry metabolism, circulation & regulation. Historical overview of vitamin d -- Evolutionary biology: mysteries of vitamin D in fish -- Evolution of human skin color and vitamin D -- Photobiology of vitamin D -- The activating enzymes of vitamin D metabolism (25- and 1[alpha]-hydroxylases) -- CYP24A1: structure, function, and physiological role -- The vitamin D binding protein DBP -- Regulation of renal and extra-renal 1[alpha]-hydroxylase -- Section II. Mechanism of action. Genome-wide perspectives on vitamin D receptor-meditated control of gene expression in target cells -- Diverse mechanisms of transcriptional regulation by the vitamin D receptor -- Structural basis for ligand activity in VDR -- Ligand independent actions of vitamin D receptor -- Vitamin D and chromatin -- Mesenchymal differentiation, epigenetic dynamics, and interactions with VDR -- Vitamin D and microRNAs -- Vitamin D sterol/VDR conformational dynamics and nongenomic actions -- Section III. Mineral and bone homeostasis. Vitamin D regulation of osteoblast function -- Osteoclastogenesis and vitamin D -- Vitamin D activities in osteocytes -- Regulation of intestinal calcium and phosphate absorption -- Calbindin-D28K and calbindin-D9K and the epithelial calcium channels TRPV5 and TRPV6 -- Calcium homeostasis and eggshell biomineralization in female chicken -- Mineralization in mammals -- Cartilage -- Vitamin D and bone: an integrated approach -- Section IV. Extra-skeletal targets. Vitamin D and the kidney -- Vitamin D and the parathyroids -- The calcium-sensing receptor and vitamin d -- Vitamin D in dentoalveolar and oral health -- The role of vitamin D and its receptor in hair follicle biology -- Vitamin D, calcium and the epidermis -- Vitamin D and the cardiovascular system -- Vitamin D brain development and function -- Vitamin D, VDR and adipose tissue: focus on cellular mechanisms -- Vitamin D and skeletal muscle -- Understanding vitamin D from mouse knockout models -- Section V. Human physiology. Pharmacology and pharmacokinetics -- Vitamin D role in the calcium and phosphorus economies -- Fetus, neonate and infant -- Consequences of perinatal vitamin D deficiency on later bone health -- Adolescence and acquisition of peak bone mass -- Pregnancy, lactation, and post-weaning recovery -- Role in reproductive biology and reproductive dysfunction in women -- Vitamin d, reproductive biology, and dysfunction in men -- Vitamin D and the renin-angiotensin system -- Parathyroid hormone, parathyroid hormone-related protein, and calcitonin -- FGF23 counter regulatory hormone for vitamin D actions on mineral metabolism, hemodynamics, and innate immunity -- Section VI. Diagnosis and management. Approach to the patient with metabolic bone disease -- Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay (REACH) technology -- Mass spectrometry assays of vitamin D metabolites -- Free vitamin d: concepts, assays, outcomes and prospects -- 25-hydroxyvitamin D assays: standardization guidelines, problems and interpretation -- Bone histomorphometry -- Radiology of rickets and osteomalcia -- High-resolution imaging techniques for bone quality assessment -- The role of vitamin D in orthopedic surgery -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the IOM Position -- The IOM-Endocrine Society controversy on recommended vitamin D targets: in support of the endocrine society position. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
"Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin DSaves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articlesTargets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency. Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications"--Publisher's description |
| 336 ## - CONTENT TYPE |
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text |
| Content type code |
txt |
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| 337 ## - MEDIA TYPE |
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computer |
| Media type code |
c |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
online resource |
| Carrier type code |
cr |
| Source |
rdacarrier |
| 655 #4 - INDEX TERM--GENRE/FORM |
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| Genre/form data or focus term |
Electronic books. |
| Non-focus term |
NATCOLCK |
| 730 0# - ADDED ENTRY--UNIFORM TITLE |
|---|
| Relationship information |
Companion to: |
| Uniform title |
Vitamin D. |
| Number of part/section of a work |
Volume 2, |
| Name of part/section of a work |
Health, disease and therapeutics. |
| 730 0# - ADDED ENTRY--UNIFORM TITLE |
|---|
| Relationship information |
Preceded by: |
| Uniform title |
Vitamin D. |
| Version |
3rd ed. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Print version: |
| Title |
Vitamin D. |
| 001 - CONTROL NUMBER |
|---|
| control field |
on1013541228 |
| 066 ## - CHARACTER SETS PRESENT |
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| Alternate G0 or G1 character set |
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AU@ |
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000061381049 |
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GBVCP |
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1010465082 |
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GBVCP |
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1023621002 |
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| 035 ## - SYSTEM CONTROL NUMBER |
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| System control number |
(OCoLC)1013541228 |
| Canceled/invalid control number |
(OCoLC)1105185479 |
| -- |
(OCoLC)1105562446 |
| -- |
(OCoLC)1141443645 |
| -- |
(OCoLC)1151725840 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
QP772.V53 |
| 060 #4 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
|---|
| Classification number |
QU 173 |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
MED |
| Subject category code subdivision |
075000 |
| Source |
bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE |
|---|
| Subject category code |
SCI |
| Subject category code subdivision |
036000 |
| Source |
bisacsh |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
MAIN |
| 590 ## - LOCAL NOTE (RLIN) |
|---|
| Local note |
Elsevier |
| 588 0# - SOURCE OF DESCRIPTION NOTE |
|---|
| -- |
Online resource; title from electronic title page (ClinicalKey, viewed December 14, 2017). |
| 590 ## - LOCAL NOTE (RLIN) |
|---|
| -- |
Elsevier ClinicalKey eBooks - WAYFless access |
| 880 00 - ALTERNATE GRAPHIC REPRESENTATION |
|---|
| Linkage |
505-00/(S |
| t |
Van Der Eerden -- |
| -- |
Introduction -- |
| -- |
Properties of Mature Osteoblasts and Osteocytes -- |
| -- |
Major Regulatory Functions of Osteoblasts and Osteocytes and Control by the Vitamin D Endocrine System -- |
| -- |
Effects of 1,25(OH)2D3 on Osteoblast Differentiation -- |
| -- |
Regulation of Intracellular Signaling Pathways by 1,25(OH)2D3 -- |
| -- |
Summary and Conclusions -- |
| -- |
References -- |
| g |
18. |
| t |
Osteoclastogenesis and Vitamin D / |
| r |
Tatsuo Suda -- |
| t |
Introduction -- |
| -- |
Regulation of Mineral Metabolism by Vitamin D, Parathyroid Hormone, and Fibroblast Growth Factor 23 -- |
| -- |
Phenotypes of Vitamin D Receptor Knockout Mice -- |
| -- |
Regulation of Osteoclastogenesis by the Receptor Activator of Nuclear Factor-κ B Ligand/Receptor Activator of Nuclear Factor-κ B/Osteoprotegerin System -- |
| -- |
In Vitro Regulation of Osteoclastogenesis by Vitamin D -- |
| -- |
In Vivo Regulation of Osteoclastogenesis by Vitamin D Compounds -- |
| -- |
Conclusion -- |
| -- |
References -- |
| g |
19. |
| t |
Vitamin D Activities in Osteocytes / |
| r |
David M. Findlay -- |
| t |
Introduction -- |
| -- |
Cell Biology of Osteocytes -- |
| -- |
Direct Actions of 1,25-Dihydroxyvitamin D on Osteocyte Maturation and Activities -- |
| -- |
Receptor Activator of Nuclear Factor κ B Ligand -- |
| -- |
Vitamin D Metabolism Within Osteocytes -- |
| -- |
Role of Osteocytes and Vitamin D in Bone Turnover -- |
| -- |
Role of Vitamin D and Osteocytes in Endocrine Feedback -- |
| -- |
Conclusions -- |
| -- |
References -- |
| g |
20. |
| t |
Regulation of Intestinal Calcium and Phosphate Absorption / |
| r |
James C. Fleet -- |
| t |
Overview of Intestinal Calcium Absorption -- |
| -- |
Overview of Intestinal Phosphate Absorption -- |
| -- |
References -- |
| g |
21. |
| t |
Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6 / |
| r |
Puneet Dhawan -- |
| t |
Introduction and General Considerations, the Calbindins -- |
| -- |
Localization and Proposed Functional Significance of the Calbindins -- |
| -- |
Regulation of Calbindin Gene Expression -- |
| -- |
Epithelial Calcium Channels -- |
| -- |
Conclusion -- |
| -- |
References -- |
| g |
22. |
| t |
Calcium Homeostasis and Eggshell Biomineralization in Female Chicken / |
| r |
Nathalie Le Roy -- |
| t |
Introduction -- |
| -- |
Mineralization Associated With Laying Hen Reproduction -- |
| -- |
Transepithelial Transfer of Calcium -- |
| -- |
Regulation of Calcium Metabolism in Hens -- |
| -- |
Acknowledgments -- |
| -- |
References. |
| 880 00 - ALTERNATE GRAPHIC REPRESENTATION |
|---|
| Linkage |
505-00/(S |
| g |
Contents note continued: |
| -- |
23. |
| t |
Mineralization in Mammals / |
| r |
Adele L. Boskey -- |
| t |
Introduction -- |
| -- |
Direct and Indirect Effects of Vitamin D and Vitamin D Metabolites on Mineralization -- |
| -- |
Methods for Quantifying Tissue Mineralization -- |
| -- |
Mechanism of Effects of Vitamin D on Mineralization -- |
| -- |
Mineralization and Mineral Properties in Systems With Vitamin D Alterations -- |
| -- |
Conclusions -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| -- |
Further Reading -- |
| g |
24. |
| t |
Cartilage / |
| r |
Zvi Schwartz -- |
| t |
Properties of Cartilage Tissues -- |
| -- |
Regulation by Vitamin D -- |
| -- |
Rapid Actions of Vitamin D and Nongenomic Mechanisms -- |
| -- |
Summary -- |
| -- |
References -- |
| g |
25. |
| t |
Vitamin D and Bone: An Integrated Approach / |
| r |
Geert Carmeliet -- |
| t |
Link Between Bone Metabolism, Calcium Homeostasis, and 1,25(OH)2D3 Activity -- |
| -- |
1,25(OH)2D3 and Bone Metabolism During a Positive Calcium Balance -- |
| -- |
Negative Calcium Balance Resulting From Insufficient Vitamin D Action -- |
| -- |
Negative Calcium Balance With Sufficient Vitamin D -- |
| -- |
Vitamin D and Fibroblast Growth Factor 23 -- |
| -- |
Conclusion -- |
| -- |
References -- |
| g |
IV. |
| t |
EXTRA-SKELETAL TARGETS -- |
| g |
26. |
| t |
Vitamin D and the Kidney / |
| r |
Rajiv Kumar -- |
| t |
Introduction -- |
| -- |
Role of the Kidney in the Metabolism of 25-Hydroxyvitamin D -- |
| -- |
Effects of Vitamin D, 25(OH)D3 and 1α, 25(OH)2D3 on the Renal Handling of Calcium and Phosphorus -- |
| -- |
Distribution and Regulation of Vitamin D-Dependent Proteins in the Kidney -- |
| -- |
Conclusion -- |
| -- |
References -- |
| g |
27. |
| t |
Vitamin D and the Parathyroids / |
| r |
Tally Naveh-Many -- |
| t |
Introduction -- |
| -- |
Parathyroid Hormone Biosynthesis -- |
| -- |
Parathyroid Hormone Gene -- |
| -- |
Development of the Parathyroid and Tissue-Specific Expression of the Parathyroid Hormone Gene -- |
| -- |
Regulation of Parathyroid Hormone Gene Expression -- |
| -- |
Summary -- |
| -- |
References -- |
| g |
28. |
| t |
Calcium-Sensing Receptor and Vitamin D / |
| r |
Geoffrey N. Hendy -- |
| t |
Introduction -- |
| -- |
Calcium-Sensing Receptor -- |
| -- |
Overview of Extracellular Ca2+ Homeostasis: Roles of Calcium-Sensing Receptor and Vitamin D Receptor -- |
| -- |
Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Involved in Ca2+ Homeostasis -- |
| -- |
Calcium-Sensing Receptor and Vitamin D Receptor in Tissues Uninvolved in Extracellular Ca2+ Homeostasis -- |
| -- |
Mouse Models of Calcium-Sensing Receptor Deletion Relative to Presentation in Humans -- |
| -- |
Conclusions -- |
| -- |
References -- |
| g |
29. |
| t |
Vitamin D in Dentoalveolar and Oral Health / |
| r |
Philippe P. Hujoel -- |
| t |
Introduction -- |
| -- |
Brief Primer on Dentoalveolar Cells and Tissues -- |
| -- |
Vitamin D Metabolism and Mechanisms of Action on Dental Cells -- |
| -- |
Vitamin D, Rickets, and the Oral Tissues -- |
| -- |
Hereditary Vitamin D-Related Diseases and Dentoalveolar Tissues -- |
| -- |
Vitamin D and Oral Health -- |
| -- |
Conclusions -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
30. |
| t |
Role of Vitamin D and Its Receptor in Hair Follicle Biology / |
| r |
Marie B. Demay -- |
| t |
Introduction -- |
| -- |
Hair Cycle -- |
| -- |
Keratinocyte Stem Cells -- |
| -- |
Pathways Important for Keratinocyte Stem Cell Function -- |
| -- |
Vitamin D Receptor Suppresses PPARγ Signaling in Keratinocyte Stem Cells -- |
| -- |
Conclusions -- |
| -- |
References -- |
| g |
31. |
| t |
Vitamin D, Calcium, and the Epidermis / |
| r |
Daniel D. Bikle -- |
| t |
Introduction -- |
| -- |
Cutaneous Production of Vitamin D and Its Biologically Active Metabolites -- |
| -- |
Regulation of Keratinocyte Differentiation -- |
| -- |
Role of Vitamin D Signaling in Skin Cancer -- |
| -- |
Role of Vitamin D Signaling in Epidermal Wound Repair -- |
| -- |
References -- |
| g |
32. |
| t |
Vitamin D and the Cardiovascular System / |
| r |
Carlos Bernal-Mizrachi -- |
| t |
Introduction -- |
| -- |
Vascular Physiology -- |
| -- |
Identification of the Vitamin D Receptor in the Vascular System -- |
| -- |
Vascular Relaxation -- |
| -- |
Structural Vascular Changes -- |
| -- |
Vascular Inflammation -- |
| -- |
Angiogenesis -- |
| -- |
Blood Coagulation and Fibrinolysis -- |
| -- |
Animal Models -- |
| -- |
Clinical Studies in Cardiovascular Disease -- |
| -- |
Conclusion -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
33. |
| t |
Vitamin D Brain Development and Function / |
| r |
John J. Mcgrath -- |
| t |
Introduction -- |
| -- |
Vitamin D Signaling in the Brain -- |
| -- |
Dietary Vitamin D Deficiency, Effect on Brain Development and Function -- |
| -- |
Effects of Excess Vitamin D on Brain Development and Function -- |
| -- |
Vitamin D Regulates Essential Processes in Normal Brain Development -- |
| -- |
Possible Neuroprotective Mechanisms of Vitamin D in the Developing Brain -- |
| -- |
Developmental Vitamin D Deficiency and Neuropsychiatric Disorders -- |
| -- |
Conclusions -- |
| -- |
References -- |
| g |
34. |
| t |
Vitamin D, Vitamin D Receptor, and Adipose Tissue: Focus on Cellular Mechanisms / |
| r |
Joellen Welsh -- |
| t |
Adipose Tissue: Storage Depot and Target for Vitamin D -- |
| -- |
Effect of Vitamin D on Adipogenesis at the Cellular Level -- |
| -- |
Impact of Vitamin D Signaling on Adiposity in Mouse Models -- |
| -- |
Translational Considerations -- |
| -- |
Conclusions and Future Directions -- |
| -- |
References -- |
| g |
35. |
| t |
Vitamin D and Skeletal Muscle / |
| r |
Christian M. Girgis -- |
| t |
Skeletal Muscle Physiology -- |
| -- |
Vitamin D Receptor in Muscle -- |
| -- |
Vitamin D and Calcium Signaling in Muscle -- |
| -- |
Vitamin D and Phosphate Signaling in Muscle -- |
| -- |
Vitamin D and Insulin Signaling in Muscle -- |
| -- |
Vitamin D, Muscle Contraction, and Strength -- |
| -- |
Vitamin D, Muscle Development, and Mass -- |
| -- |
Vitamin D, Muscle Injury, and Repair -- |
| -- |
Vitamin D and Age-Related Changes in Muscle -- |
| -- |
Vitamin D and Bone Muscle Cross-Talk -- |
| -- |
Conclusions and Future Directions -- |
| -- |
References -- |
| g |
36. |
| t |
Understanding Vitamin D From Mouse Knockout Models / |
| r |
Denshun Miao -- |
| t |
Vitamin D Metabolism -- |
| -- |
1,25 Dihydroxyvitamin D/Vitamin D Receptor System and Mineral and Skeletal Homeostasis -- |
| -- |
Extraskeletal Actions of 1,25 dihydroxyvitamin D -- |
| -- |
Conclusion -- |
| -- |
References -- |
| -- |
Further Reading -- |
| g |
V. |
| t |
HUMAN PHYSIOLOGY -- |
| g |
37. |
| t |
Pharmacology and Pharmacokinetics / |
| r |
Kerry S. Jones -- |
| t |
Overview -- |
| -- |
Vitamin D Absorption -- |
| -- |
Kinetics of Cutaneous Synthesis -- |
| -- |
Tissue Distribution -- |
| -- |
Metabolism and Determinants of Metabolic Fate of Vitamin D -- |
| -- |
Half-Lives of Vitamin D Metabolites -- |
| -- |
Factors Influencing Vitamin D Half-Life -- |
| -- |
Pharmacokinetics of Bound and Free Vitamin D Metabolites -- |
| -- |
Influence of Vitamin D-Binding Protein Genotype and Concentration on Vitamin D Metabolism and 25(OH)D Half-Life -- |
| -- |
Dose-Response to Vitamin D Supplementation -- |
| -- |
3-Epimer of 25(OH)D and 1,25(OH)2D -- |
| -- |
Catabolism and Excretion -- |
| -- |
Vitamin D Toxicity -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
38. |
| t |
Vitamin D Role in the Calcium and Phosphorus Economies / |
| r |
Laura A. Graeff-Armas -- |
| t |
Introduction -- |
| -- |
Overview of the Calcium Economy -- |
| -- |
Overview of the Phosphorus Economy -- |
| -- |
Calcium and Phosphorus Absorptive Inputs -- |
| -- |
Physiological Sources of Vitamin D Activity -- |
| -- |
Optimal Vitamin D Status -- |
| -- |
Summary and Conclusions -- |
| -- |
References -- |
| g |
39. |
| t |
Fetus, Neonate, and Infant / |
| r |
Christopher S. Kovacs -- |
| t |
Overview of Calcium Metabolism in the Fetus -- |
| -- |
Animal Data Relevant to Vitamin D and the Fetus -- |
| -- |
Human Data Relevant to Vitamin D and the Fetus -- |
| -- |
Overview of Calcium Metabolism in the Neonate and Infant -- |
| -- |
Animal Data Relevant to Vitamin D and the Neonate and Infant -- |
| -- |
Human Data Relevant to Vitamin D and the Neonate and Infant -- |
| -- |
Conclusions -- |
| -- |
References -- |
| g |
40. |
| t |
Consequences of Perinatal Vitamin D Deficiency on Later Bone Health / |
| r |
Nicholas C. Harvey -- |
| t |
Introduction -- |
| -- |
Vitamin D Physiology and Epidemiology in Pregnancy -- |
| -- |
Lifecourse Determinants of Osteoporosis -- |
| -- |
Maternal Vitamin D Supplementation During Pregnancy and Offspring Bone Health -- |
| -- |
Maternal Vitamin D Supplementation During Pregnancy and Offspring Bone Health: The MAVIDOS Trial -- |
| -- |
Conclusion -- |
| -- |
Acknowledgment -- |
| -- |
References -- |
| g |
41. |
| t |
Adolescence and Acquisition of Peak Bone Mass / |
| r |
Connie Weaver -- |
| t |
Introduction -- |
| -- |
Pubertal Bone Acquisition -- |
| -- |
Sex and Race Differences -- |
| -- |
Serum 25(OH)D in Children and Adolescents -- |
| -- |
Vitamin D and Intermediate Endpoints of Vitamin D and Bone Metabolism -- |
| -- |
Vitamin D and Other Predictors of Calcium Retention -- |
| -- |
Vitamin D and Bone -- |
| -- |
Vitamin D and Muscle -- |
| -- |
Vitamin D Requirements in Children and Adolescents -- |
| -- |
Summary and Conclusions -- |
| -- |
References -- |
| g |
42. |
| t |
Pregnancy, Lactation, and Postweaning Recovery / |
| r |
Christopher S. |
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Machine generated contents note: |
| t |
VOLUME I -- |
| g |
I. |
| t |
HISTORY, CHEMISTRY METABOLISM, CIRCULATION & REGULATION -- |
| g |
1. |
| t |
Historical Overview of Vitamin D / |
| r |
Hector F. Deluca -- |
| t |
Discovery of the Vitamins -- |
| -- |
Discovery of the Physiological Functions of Vitamin D -- |
| -- |
Discovery of the Hormonal Form of Vitamin D -- |
| -- |
Acknowledgment -- |
| -- |
References -- |
| g |
2. |
| t |
Evolutionary Biology: Mysteries of Vitamin D in Fish / |
| r |
David R. Fraser -- |
| t |
Biological Distribution of Vitamin D -- |
| -- |
Evolutionary Origins of Vitamin D -- |
| -- |
Evolution of Vitamin D Function -- |
| -- |
Origin of Vitamin D in Fish -- |
| -- |
Functional Metabolism of Vitamin D in Fish -- |
| -- |
Possible Role for Sunlight in the Origin of Vitamin D in Fish -- |
| -- |
Vitamin D Function in Fish -- |
| -- |
Transport of Vitamin D and Its Metabolites -- |
| -- |
Vitamin D Toxicity From Oral Ingestion -- |
| -- |
References -- |
| g |
3. |
| t |
Evolution of Human Skin Color and Vitamin D / |
| r |
Nina G. Jablonski -- |
| t |
Introduction -- |
| -- |
Solar Context of Human Skin Color Evolution -- |
| -- |
Nature of the Selective Factors Leading to the Evolution of Skin Pigmentation in Early Homo -- |
| -- |
Folate Conservation and the Evolution of Permanent Protective Pigmentation -- |
| -- |
Early Hominin Dispersal Out of the Tropics and Vitamin D Production -- |
| -- |
Evolution of Skin Pigmentation in Homo sapiens -- |
| -- |
Effects of Cultural Buffering, Rapid Migrations, and Modern Lifestyles on Skin Color and Vitamin D -- |
| -- |
References -- |
| -- |
Further Reading -- |
| g |
4. |
| t |
Photobiology of Vitamin D / |
| r |
Michael F. Holick -- |
| t |
Introduction -- |
| -- |
Historical Perspective -- |
| -- |
Photobiology of Vitamin D -- |
| -- |
Role of Sunlight and Dietary Vitamin D in Bone Health, Overall Health, and Well-being -- |
| -- |
Sunlight, Vitamin D, and Skin Cancer -- |
| -- |
Conclusions -- |
| -- |
References -- |
| -- |
Further Reading -- |
| g |
5. |
| t |
Activating Enzymes of Vitamin D Metabolism (25- and 1α-Hydroxylases) / |
| r |
Martin Kaufmann -- |
| t |
Introduction -- |
| -- |
General Information Regarding Vitamin D Hydroxylases -- |
| -- |
Vitamin D3-25-Hydroxylases -- |
| -- |
25-Hydroxyvitamin D-1α-hydroxylase -- |
| -- |
Additional Topics -- |
| -- |
References -- |
| g |
6. |
| t |
CYP24A1: Structure, Function, and Physiological Role / |
| r |
Glenville Jones -- |
| t |
Introduction -- |
| -- |
CYP24A1-Catalyzed Pathways -- |
| -- |
C24-Oxidation Pathway -- |
| -- |
C23-Hydroxylation Pathway -- |
| -- |
CYP24A1, a Multifunctional Enzyme -- |
| -- |
Biological Relevance of the C24-Oxidation Pathway -- |
| -- |
Structure-Function Relationships -- |
| -- |
Mutations of CYP24A1 and Idiopathic Infantile Hypercalcemia -- |
| -- |
Preclinical Models of Idiopathic Infantile Hypercalcemia -- |
| -- |
Putative CYP24A1 Involvement in Other Systems -- |
| -- |
CYP24A1 in Chronic Kidney Disease -- |
| -- |
Role of 24,25(OH)2D in Chondrocyte Maturation -- |
| -- |
24,25(OH)2D and Fracture Repair -- |
| -- |
Perspectives -- |
| -- |
References -- |
| g |
7. |
| t |
Vitamin D-Binding Protein / |
| r |
Steven Pauwels -- |
| t |
Summary -- |
| -- |
Introduction -- |
| -- |
Vitamin D-Binding Protein: Gene and Protein Structure -- |
| -- |
Functions of Vitamin D-Binding Protein -- |
| -- |
Vitamin D-Binding Protein-Actin Complex -- |
| -- |
Conclusions and Perspectives -- |
| -- |
References -- |
| g |
8. |
| t |
Regulation of Renal and Extrarenal 1α-Hydroxylase / |
| r |
Martin Hewison -- |
| t |
Introduction -- |
| -- |
Renal la-Hydroxylase -- |
| -- |
Extrarenal Expression of 1α-Hydroxylase -- |
| -- |
Conclusions and Future Prospects -- |
| -- |
References -- |
| g |
II. |
| t |
MECHANISM OF ACTION -- |
| g |
9. |
| t |
Genome-Wide Perspectives on Vitamin D Receptor--Mediated Control of Gene Expression in Target Cells / |
| r |
Nancy A. Benkusky -- |
| t |
Introduction -- |
| -- |
Biology of Vitamin D -- |
| -- |
Metabolic Activation of Vitamin D -- |
| -- |
Overview of the Vitamin D Receptor: The Protein, Its Structure, and Function -- |
| -- |
Recent Advances in the Mechanisms of Action of Vitamin D -- |
| -- |
Advances in Understanding the Regulation of the Vitamin D Receptor Gene -- |
| -- |
Exploiting Humanized VDR Transgenic Mice to Understand Expression, Regulation, and VDR Protein Function In Vivo -- |
| -- |
Establishing a Humanized Mouse Model for the Study of Human Disease -- |
| -- |
Summary and Conclusions -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
10. |
| t |
Diverse Mechanisms of Transcriptional Regulation by the Vitamin D Receptor / |
| r |
Manuella Bouttier -- |
| t |
Introduction -- |
| -- |
Interplay Between Transforming Growth Factor β and Vitamin D Receptor Signaling -- |
| -- |
Vitamin D Receptor and Transcription Factor Activator Protein-1 -- |
| -- |
Interplay Between VDR and JAK/STAT Signaling in Immunity -- |
| -- |
Regulation of Wnt Signaling by the Vitamin D Receptor: A Molecular Basis for Cancer Prevention -- |
| -- |
Control of FoxO Protein Function by the Vitamin D Receptor -- |
| -- |
Regulation of the c-MYC/MXD1 Network by the Hormone-Bound Vitamin D Receptor -- |
| -- |
Multiple Mechanisms of Regulation of NF-κ B Signaling by the Hormone-Bound Vitamin D Receptor -- |
| -- |
Insights Into Transcriptional Regulation by the Vitamin D Receptor from Genomics Studies -- |
| -- |
Conclusions -- |
| -- |
References -- |
| g |
11. |
| t |
Structural Basis for Ligand Activity in Vitamin D Receptor / |
| r |
Natacha Rochel -- |
| t |
Introduction -- |
| -- |
1α, 25-Dihydroxyvitamin D3 Recognition by Vitamin D Receptor -- |
| -- |
Natural Metabolites -- |
| -- |
Other Vitamin D Receptor Natural Ligands -- |
| -- |
Secosteroidal Analogs of 1α, 25-Dihydroxyvitamin D3 -- |
| -- |
Structures of Vitamin D Receptor With Analogs That Induce Structural Rearrangements -- |
| -- |
Synthetic Mimics of 1α,25-Dihydroxyvitamin D3 -- |
| -- |
Conclusions and Perspectives -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
12. |
| t |
Ligand-Independent Actions of Vitamin D Receptor / |
| r |
Daniel Metzger -- |
| t |
Vitamin D Receptor -- |
| -- |
Skeletal Defects Induced by Impaired Vitamin D Receptor Signaling -- |
| -- |
Ligand-Independent Role of Vitamin D Receptor in Hair Cycle -- |
| -- |
Unliganded Vitamin D Receptor Repressive Activities Induce Severe Skeletal Defects -- |
| -- |
Toward Improved Diagnosis and Treatments of Hereditary Vitamin D Resistant Rickets Patients -- |
| -- |
Conclusion and Perspectives -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
13. |
| t |
Vitamin D and Chromatin / |
| r |
Carsten Carlberg -- |
| t |
Introduction -- |
| -- |
Nuclear Receptor Superfamily Member Vitamin D Receptor -- |
| -- |
Genome-Wide Location of Vitamin D Receptor-Binding Sites -- |
| -- |
CTCF as Organizer of Vitamin D-Dependent Chromatin Domains -- |
| -- |
Impact of Epigenomics -- |
| -- |
Vitamin D-Triggered Epigenome Changes -- |
| -- |
Chromatin Model of Vitamin D Signaling Emerges -- |
| -- |
Vitamin D Signaling In Vivo -- |
| -- |
Conclusion -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
14. |
| t |
Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions With VDR / |
| r |
J. Wesley Pike -- |
| t |
Genetic Control of Mesenchymal Lineage Cells -- |
| -- |
Epigenetic Fate Determination -- |
| -- |
Osteoblast Enhancer Complex: Consolidated and Dispersed -- |
| -- |
Dynamics of Transdifferentiation -- |
| -- |
Conclusions -- |
| -- |
Conflict of Interest -- |
| -- |
References -- |
| g |
15. |
| t |
Vitamin D and MicroRNAs / |
| r |
Thomas S. Lisse -- |
| t |
Introduction -- |
| -- |
MicroRNAs: The Posttranscriptional Age -- |
| -- |
Complexity of MicroRNA Regulation, Biogenesis, and Posttranscriptional Regulatory Actions -- |
| -- |
Nuclear Receptors and MicroRNAs -- |
| -- |
Duality Among MicroRNAs and the Vitamin D Synthesis, Metabolism, and Signaling Systems -- |
| -- |
Interplay Between Vitamin D and MicroRNAs in Biological Systems -- |
| -- |
Strategies for MicroRNA and Target Identification for Vitamin D Research -- |
| -- |
Concluding Remarks -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
16. |
| t |
Vitamin D Sterol/Vitamin D Receptor Conformational Dynamics and Nongenomic Actions / |
| r |
Anthony W. Norman -- |
| t |
Introduction -- |
| -- |
1α, 25(OH)2 Vitamin D3 Regulation of Genomic Versus Nongenomic Signaling -- |
| -- |
Vitamin D3 Sterol Chemistry -- |
| -- |
1,25(OH)2D3-Mediated Rapid, Nongenomic Responses -- |
| -- |
Plasma Membrane Vitamin D Receptor -- |
| -- |
Vitamin D Receptor Conformational Ensemble Model -- |
| -- |
Vitamin D Receptor Ligand Specificity: Does an Unliganded Vitamin D Receptor Ever Exist In Vivo-- |
| -- |
References -- |
| g |
III. |
| t |
MINERAL AND BONE HOMEOSTASIS -- |
| g |
17. |
| t |
Vitamin D Regulation of Osteoblast Function / |
| r |
Bram C.J. |
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Contents note continued: |
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Renin-Angiotensin System -- |
| -- |
Vitamin D Regulation of the Renin-Angiotensin System -- |
| -- |
Vitamin D and the Renin-Angiotensin System in Disease -- |
| -- |
Conclusion -- |
| -- |
References -- |
| g |
46. |
| t |
Parathyroid Hormone, Parathyroid Hormone--Related Protein, and Calcitonin / |
| r |
John J. Wysolmerski -- |
| t |
Parathyroid Hormone -- |
| -- |
Parathyroid Hormone--Related Protein -- |
| -- |
Calcitonin -- |
| -- |
References -- |
| g |
47. |
| t |
FGF23 Counter-Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and Innate Immunity / |
| r |
L. Darryl Quarles -- |
| t |
Introduction -- |
| -- |
Parathyroid Hormone--Vitamin D Axis: Key Regulator of Calcium Homeostasis -- |
| -- |
Fibroblast Growth Factor-23/α-Klotho -- |
| -- |
Fibroblast Growth Factor-23 Endocrine Networks -- |
| -- |
Noncanonical α-Klotho and Fibroblast Growth Factor-23 Signaling -- |
| -- |
Conclusions -- |
| -- |
References -- |
| g |
VI. |
| t |
DIAGNOSIS AND MANAGEMENT -- |
| g |
48. |
| t |
Approach to the Patient With Metabolic Bone Disease / |
| r |
Michael P. Whyte -- |
| t |
Introduction -- |
| -- |
Diagnostic Evaluation -- |
| -- |
Biochemical Investigation -- |
| -- |
Histopathological Assessment -- |
| -- |
Treatment -- |
| -- |
Conclusions -- |
| -- |
Acknowledgments -- |
| -- |
References -- |
| g |
49. |
| t |
Detection of 1,25-Dihydroxyvitamin D in Human Serum Using Receptor Assisted Chemiluminescent Hormone Assay Technology / |
| r |
Bruce W. Hollis -- |
| t |
Introduction -- |
| -- |
Methodology -- |
| -- |
Identification of the DNA Consensus Sequence of the Immunoglobulin G VH and VL Gene, Expressed by Hybridoma Clone 11B4 -- |
| -- |
Preparation of the Assay Reagents -- |
| -- |
Assay Format and Performance -- |
| -- |
Discussion -- |
| -- |
References -- |
| g |
50. |
| t |
Mass Spectrometry Assays of Vitamin D Metabolites / |
| r |
Ravinder J. Singh -- |
| t |
Introduction -- |
| -- |
Approaches and Utility of Vitamin D Metabolite Measurements in the Clinical Laboratory Setting -- |
| -- |
Overview of Methodology for Analysis of Circulating Vitamin D Metabolites by LC-MS/MS -- |
| -- |
Application of LC-MS/MS to the Study of Vitamin D Metabolism in Animal Models -- |
| -- |
Future Directions -- |
| -- |
References -- |
| g |
51. |
| t |
Free Vitamin D: Concepts, Assays, Outcomes, and Prospects / |
| r |
Carrie M. Nielson -- |
| t |
Introduction -- |
| -- |
Metabolism -- |
| -- |
Transportation and Internalization: Free Hormone Hypothesis and Bioavailable Ligand -- |
| -- |
Vitamin D-Binding Protein Genotype -- |
| -- |
Free Vitamin D: Mathematical Estimation -- |
| -- |
Free Vitamin D: Direct Physical Measurement -- |
| -- |
Potential Utility of Free 25(OH)D for Clinical- and Population-Based Detection of Vitamin D Deficiency -- |
| -- |
Conclusions and Knowledge Gaps -- |
| -- |
References -- |
| g |
52. |
| t |
25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems, and Interpretation / |
| r |
Neil C. Binkley -- |
| t |
Introduction -- |
| -- |
Vitamin D Standardization Program Objectives -- |
| -- |
Standardization and Traceability -- |
| -- |
Vitamin D Standardization Program Standardization Protocols -- |
| -- |
Performance Testing/Quality Assessment of Assays for Vitamin D Metabolites -- |
| -- |
Vitamin D Standardization Program Efforts Going Into the Future -- |
| -- |
Summary and Conclusions -- |
| -- |
References -- |
| g |
53. |
| t |
Bone Histomorphometry / |
| r |
David W. Dempster -- |
| t |
Introduction -- |
| -- |
Bone Biopsy -- |
| -- |
Histomorphometry -- |
| -- |
Assessment of Mineralization -- |
| -- |
Histological Diagnosis of Osteomalacia -- |
| -- |
Assessment of Bone Turnover -- |
| -- |
Assessment of Remodeling Balance -- |
| -- |
Assessment of Bone Structure -- |
| -- |
Influence of Vitamin D Status on Bone Histomorphometry -- |
| -- |
Future Developments -- |
| -- |
References -- |
| g |
54. |
| t |
Radiology of Rickets and Osteomalacia / |
| r |
Judith E. Adams -- |
| t |
Introduction and Historical Aspects -- |
| -- |
Vitamin D Deficiency -- |
| -- |
Renal Osteodystrophy -- |
| -- |
Renal Tubular Defects and Hypophosphatemia -- |
| -- |
Differential Diagnoses -- |
| -- |
Vitamin D Intoxication -- |
| -- |
Conclusions -- |
| -- |
References -- |
| g |
55. |
| t |
High-Resolution Imaging Techniques for Bone Quality Assessment / |
| r |
Sharmila Majumdar -- |
| t |
Introduction -- |
| -- |
X-ray Computed Tomography -- |
| -- |
Magnetic Resonance Imaging -- |
| -- |
References -- |
| g |
56. |
| t |
Role of Vitamin D in Orthopedic Surgery / |
| r |
Joseph M. Lane -- |
| t |
Introduction -- |
| -- |
Impact on Orthopedic Trauma -- |
| -- |
Impact on Pediatric Orthopedics -- |
| -- |
Impact on Total Joint Arthroplasty -- |
| -- |
References -- |
| -- |
Introduction to Chapters 57A and 57B References -- |
| g |
57A. |
| t |
IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position / |
| r |
Cliff Rosen -- |
| t |
Introduction -- |
| -- |
Vitamin D Status and Bone Health in Adults and the Elderly -- |
| -- |
Vitamin D and Extraskeletal Health -- |
| -- |
Lessons From Recently Updated Guidelines on Vitamin D Supplementation -- |
| -- |
Vitamin D and Human Health: What is the Optimal Vitamin D Status -- |
| -- |
Summary of Recommendations -- |
| -- |
Highlights -- |
| -- |
References -- |
| g |
57B. |
| t |
IOM---Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position / |
| r |
Michael F. Holick -- |
| g |
Section I |
| t |
Defining the Disagreement Between IOM and Endocrine Society -- |
| g |
Section II |
| t |
Scientific Basis for Why IOM Versus Endocrine Society Values Differ in Terms of Bone Health -- |
| g |
Section III |
| t |
Toxicity and Perceptions of Risk of Higher Vitamin D Intakes: Higher-Dose Clinical Trials and Epidemiology U-Shaped Risk Findings -- |
| g |
Section IV |
| t |
Extraskeletal Effects of Vitamin D -- |
| g |
Section V |
| t |
Extraskeletal Effects: Cross-Sectional Observations Versus the Findings of Double-Blind, Randomized Clinical Trials -- |
| g |
Section VI |
| t |
Emerging Benefits of Higher Vitamin D: Life Expectancy -- |
| g |
Section VII |
| t |
New Evidence That Vitamin D Lowers Risk of Preterm Birth -- |
| g |
Section VIII |
| t |
Conclusion. |
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